Rybelsus and Ozempic are two weight loss drugs that have been rapidly rising in fame. From commercials on TV to celebrity endorsements and people posting their success stories on social media, it is likely you’ve heard of at least one of these medications. If not, we’ll give a brief overview of each and explain the differences below. If you would like a more general overview, check out this article.

Intro to Rybelsus

Rybelsus, also known as semaglutide, belongs to a class of medications called GLP-1 receptor agonists. Unlike traditional insulin injections, Rybelsus is taken orally, making it more accessible and convenient for patients. This once-daily pill works by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1), which stimulates insulin production and reduces glucose production by the liver. By increasing insulin secretion and decreasing glucagon secretion, Rybelsus helps lower blood sugar levels in individuals with type 2 diabetes.

Approved by the FDA in September 2019, Rybelsus was intended simply to be an oral version of Ozempic. The FDA approved Rybelsus for the treatment of diabetes specifically, but it is often prescribed off-label, or prescribed for something other than diabetes, effectively making it a weight loss medication as well.

Intro to Ozempic

Ozempic, much like Rybelsus, contains the active ingredient semaglutide, so it works identically. It belongs to a class of medications called GLP-1 receptor agonists, mimics the hormone glucagon-like peptide-1 (GLP-1), and is approved for diabetes. Ozempic, however, was approved in December 2017 and is injected under the skin rather than taken by mouth.

What’s the Difference?

Effectively, the only difference between Rybelsus and Ozempic is how it is taken. Both contain the same active ingredient, are made by the same company, work the same way and treat the same condition. The only real difference is that Rybelsus is a pill and Ozempic is an injection. The only reason they have different names in the first place is because they have two separate approvals by the FDA.

Why Bother with Different Names?

The way FDA approval works is part of the reason why there are so many names for the same medications. Ozempic, Wegovy and Rybelsus are all the same drug, so why do they have different names? Doesn’t that just make it more confusing?

For the consumer, yes it does, but it also serves a purpose. Every time the FDA approves a new drug, they must be given evidence that it works to treat a particular condition. Clinical trials are lengthy and costly. If Novo Nordisk, the maker of semaglutide, wanted to get it approved for multiple conditions, they would have to fund multiple studies. When there is high competition, it is in the best interest of a pharmaceutical company to get their drug approved as quickly as possible. Separating drugs to treat different conditions, even when they contain the same ingredients, can be quicker and easier. There are also marketing benefits to a company having multiple brands, even when they are essentially the same product.

Which is More Effective: Rybelsus or Ozempic?

By comparing the clinical trials that helped get them approved by the FDA, we can see that both are incredibly similar in effectiveness. Considering they are the same chemical, this is no surprise. A 2023 clinical trial called OASIS 1 found that the estimated mean bodyweight change from baseline to week 68 was –15.1% for oral semaglutide, or Rybelsus. The STEP 1 clinical trial found the mean change in body weight from baseline to week 68 was −14.9% in the injectable semaglutide, or Ozempic, group. In simple terms, there was only a 0.2% difference in weight lost when comparing Ozempic vs Rybelsus, a number far too small to say one is better.

Which One Is Right for Me?

If you’re trying to decide between Ozempic or Rybelsus, the most relevant question is how you want to take your semaglutide. Are you comfortable with self-injections, or would you prefer the ease of a pill? Would you rather take it once a week, or once a day? Would you rather keep your medication refrigerated or be able to bring it around with you?

Before jumping into using semaglutide for weight loss, however, it's crucial to talk to a healthcare provider like the medical team at MD Exam. We have a simple questionnaire where you share your medical history and we set you up with a personalized weight loss plan. We have seen the most success with semaglutide and tirzepatide, but we are dedicated to finding the right fit for you. Both medications have proven their effectiveness and are tolerated differently on a person-by-person basis.

Final Notes

The comparison between Rybelsus and Ozempic reveals that both medications, despite being administered differently, showcase similar effectiveness in weight loss. The choice between the two ultimately boils down to personal preference regarding administration method – whether one prefers the convenience of a pill or the efficacy of an injection. Understanding these differences and consulting with a healthcare provider can help individuals make an informed decision tailored to their unique needs and preferences.

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